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<p>A series of dispiro-fused imidazothiazolotriazine-pyrrolidine-oxindoles with two ester groups in the pyrrolidine ring was synthesized by the [3+2] cycloaddition of azomethine ylides to dipolarophiles, functionalized imidazothiazolotriazines bearing tetrasubstituted double bonds. The treatment of the synthesized compounds with bases resulted in the selective hydrolysis of one of the two ester groups thus providing possibility for the target modification of the compound functionality and synthesis of the corresponding carboxylic acids and then amides in good yields.</p>

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Diastereoselective synthesis of functionalized dispiro[imidazothiazolotriazine-pyrrolidine-oxindoles] based on the reaction of azomethine ylides with tetrasubstituted alkenes

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • A. A. Streltsov,
  • A. N. Izmest’ev,
  • D. B. Vinogradov,
  • A. N. Kravchenko,
  • G. A. Gazieva

摘要

A series of dispiro-fused imidazothiazolotriazine-pyrrolidine-oxindoles with two ester groups in the pyrrolidine ring was synthesized by the [3+2] cycloaddition of azomethine ylides to dipolarophiles, functionalized imidazothiazolotriazines bearing tetrasubstituted double bonds. The treatment of the synthesized compounds with bases resulted in the selective hydrolysis of one of the two ester groups thus providing possibility for the target modification of the compound functionality and synthesis of the corresponding carboxylic acids and then amides in good yields.