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<p>A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.</p>

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Synthesis of a new hybrid compound based on camptothecin and lithocholic acid and study of its antitumor properties

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • N. M. Chobanov,
  • L. U. Dzhemileva,
  • U. M. Dzhemilev,
  • V. A. D’yakonov

摘要

A hybrid compound containing fragments of lithocholic acid and the antitumor alkaloid camptothecin linked to each other through an anhydride and an ester group with a succinic acid fragment was synthesized for the first time. The resulting compound was found to be an effective inducer of apoptosis and capable of causing cell cycle arrest.