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<p>The graft polymerization of acrylamide and methyl methacrylate onto a mixture of collagen and chitosan in an acetic acid dispersion in the presence of the complex of triethylborane with hexamethylenediamine has been studied. It was found that monomer conversion depends on the molecular weight of chitosan and the nature of the monomer, while the resulting terpolymers have a cross-linked structure. The models of hydrogel scaffolds based on terpolymers of collagen—chitosan—(meth)acrylic monomer were developed and water absorption and stability in buffer solutions were determined for these materials. The cytotoxicity of the obtained scaffold models was assessed using the MTT assay on human dermal fibroblast cultures. The results suggest that some samples are promising materials for regenerative medicine.</p>

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Scaffold models based on terpolymers of collagen—chitosan—(meth)acrylic monomer synthesized in the presence of an amine complex of triethylborane

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Yu. L. Kuznetsova,
  • K. S. Gushchina,
  • A. S. Vavilova,
  • K. S. Lobanova,
  • K. S. Gubareva,
  • V. O. Rumyantseva,
  • M. N. Egorikhina,
  • I. N. Charykova,
  • D. G. Fukina,
  • L. L. Semenycheva

摘要

The graft polymerization of acrylamide and methyl methacrylate onto a mixture of collagen and chitosan in an acetic acid dispersion in the presence of the complex of triethylborane with hexamethylenediamine has been studied. It was found that monomer conversion depends on the molecular weight of chitosan and the nature of the monomer, while the resulting terpolymers have a cross-linked structure. The models of hydrogel scaffolds based on terpolymers of collagen—chitosan—(meth)acrylic monomer were developed and water absorption and stability in buffer solutions were determined for these materials. The cytotoxicity of the obtained scaffold models was assessed using the MTT assay on human dermal fibroblast cultures. The results suggest that some samples are promising materials for regenerative medicine.