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<p>A series of novel analogs of well-known antitumor agent combretastatin A4 of the isoxazole series were obtained. The target compounds were synthesized using sulfonylation reaction of 4-amino-5-methyl-3-(trimethoxyphenyl)isoxazole. Antiproliferative activity of the obtained isoxazole derivatives against four cancer cell lines (HCT116, PC3, A2780, A2780cis) was investigated.</p>

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Synthesis and investigation of antiproliferative activity of novel analogs of combretastatin A4 of isoxazole series

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • M. S. Kuzmina,
  • N. E. Astakhova,
  • D. A. Vasilenko,
  • K. N. Sedenkova,
  • Yu. K. Grishin,
  • Yu. A. Gracheva,
  • E. R. Milaeva,
  • E. B. Averina

摘要

A series of novel analogs of well-known antitumor agent combretastatin A4 of the isoxazole series were obtained. The target compounds were synthesized using sulfonylation reaction of 4-amino-5-methyl-3-(trimethoxyphenyl)isoxazole. Antiproliferative activity of the obtained isoxazole derivatives against four cancer cell lines (HCT116, PC3, A2780, A2780cis) was investigated.