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<p>Modification of ketoximes containing 1,3-dioxane moiety in reactions with alkyl halides, bifunctional compounds, and acylation agents was studied, and anticoagulation and antiplatelet activity of both starting compounds and products was investigated. The synthesized ethers, esters, and carbamates showed anticoagulant activity at the level of acetylsalicylic acid, whereas phenylcarbamoyl oxime containing a cycloacetal group was found to be comparable to sodium etamsylate in pro-aggregation activity and enhancement of platelet aggregation.</p>

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Synthesis, properties, and study of anticoagulant and antiplatelet activity of ketoximes containing the 1,3-dioxane moiety

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Ya. S. Artamonova,
  • A. I. Poptsov,
  • Yu. G. Borisova,
  • A. A. Golovanov,
  • G. Z. Raskildina,
  • S. S. Zlotsky,
  • R. M. Sultanova

摘要

Modification of ketoximes containing 1,3-dioxane moiety in reactions with alkyl halides, bifunctional compounds, and acylation agents was studied, and anticoagulation and antiplatelet activity of both starting compounds and products was investigated. The synthesized ethers, esters, and carbamates showed anticoagulant activity at the level of acetylsalicylic acid, whereas phenylcarbamoyl oxime containing a cycloacetal group was found to be comparable to sodium etamsylate in pro-aggregation activity and enhancement of platelet aggregation.