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<p>A method for the synthesis of bis(dispiro[indolinone-pyrrolidine-imidazolones]) spirocyclic motif of which is linked by the alkyl spacers trough the <i>para</i>-positions of aryl substituents in the pyrrolidone ring was developed. The starting compound, <i>p</i>-hydroxybenzaldehyde, was alkylated with α,ω-dihaloalkanes C<sub>4</sub>—C<sub>10</sub>, the resulting product was involved in the reaction with either 2-thiohydantoin or the glycine—isothiocyanate mixture and, finally, azomethine ylide generated from isatin and <i>N</i>-methylglycine was added to the resulting bis-arylidenethiohydantoins.</p>

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Synthesis of bis(dispiro[indolinone-pyrrolidine-imidazolones])

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • V. S. Polyakov,
  • E. V. Pervakova,
  • N. V. Zyk,
  • E. K. Beloglazkina

摘要

A method for the synthesis of bis(dispiro[indolinone-pyrrolidine-imidazolones]) spirocyclic motif of which is linked by the alkyl spacers trough the para-positions of aryl substituents in the pyrrolidone ring was developed. The starting compound, p-hydroxybenzaldehyde, was alkylated with α,ω-dihaloalkanes C4—C10, the resulting product was involved in the reaction with either 2-thiohydantoin or the glycine—isothiocyanate mixture and, finally, azomethine ylide generated from isatin and N-methylglycine was added to the resulting bis-arylidenethiohydantoins.