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<p>New trisubstituted 1,2,4-triazoles were synthesized which contain two aromatic substituents at positions 1 and 3 of the heterocycle, as well as a varied one at position 5 which includes sp<sup>3</sup>-hybridized carbon atoms. The obtained compounds, differing, in particular, in lipophilicity, number of heteroatoms, size/presence of a ring, were studied for antiviral activity against the influenza virus A/Puerto Rico/8/34 (H1N1), as well as for antifungal activity against fungi of the genus <i>C. albicans</i> ATCC 10231 and antibacterial activity against laboratory strain of <i>E. coli</i> MG1655.</p>

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Synthesis of new 4-(5-R-1-phenyl-1H-1,2,4-triazol-3-yl)benzamides

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • A. A. Firsova,
  • V. V. Chernyshov,
  • I. L. Esaulkova,
  • T. L. Salakhov,
  • A. Yu. Saliev,
  • R. A. Ivanov,
  • V. V. Zarubaev,
  • S. Z. Vatsadze

摘要

New trisubstituted 1,2,4-triazoles were synthesized which contain two aromatic substituents at positions 1 and 3 of the heterocycle, as well as a varied one at position 5 which includes sp3-hybridized carbon atoms. The obtained compounds, differing, in particular, in lipophilicity, number of heteroatoms, size/presence of a ring, were studied for antiviral activity against the influenza virus A/Puerto Rico/8/34 (H1N1), as well as for antifungal activity against fungi of the genus C. albicans ATCC 10231 and antibacterial activity against laboratory strain of E. coli MG1655.