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<p>The reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids with 2-aminopyrimidines afforded the corresponding salts. Their structures were confirmed by IR spectroscopy, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, and X-ray diffraction. A number of new compounds were evaluated for anxiolytic activity using the open field test and the light-dark box test. The lead compound with potential anti-anxiety properties was revealed.</p>

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Synthesis and evaluation of anxiolytic activity of 2-aminopyrimidin-1-ium 4-aryl-2-hydroxy-4-oxobut-2-enoates

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • V. D. Polezhaeva,
  • N. A. Pulina,
  • A. I. Krasnova,
  • M. V. Dmitriev

摘要

The reaction of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids with 2-aminopyrimidines afforded the corresponding salts. Their structures were confirmed by IR spectroscopy, 1H and 13C NMR spectroscopy, and X-ray diffraction. A number of new compounds were evaluated for anxiolytic activity using the open field test and the light-dark box test. The lead compound with potential anti-anxiety properties was revealed.