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<p>Podands bearing phthalimide and dihydro(azolo)pyrimidine or pyrazolopyridine moieties at the ends of the oligooxyethylene spacer were synthesized. The cytotoxicity and antiviral activity against the SARS-CoV-2 coronavirus of the synthesized compounds were evaluated, and these compounds were assessed as potential inhibitors of the main protease (Mpro) of SARS-CoV-2 compared to compounds lacking this podand moiety.</p>

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Podands with phthalimide and dihydro(azolo)pyrimidine or pyrazolopyridine moieties, their cytotoxicity and antiviral activity

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • E. S. Filatova,
  • O. V. Fedorova,
  • I. G. Ovchinnikova,
  • V. I. Uvarova,
  • E. V. Khvatov,
  • M. K. Kaleda,
  • L. I. Kozlovskaya,
  • G. L. Rusinov,
  • V. N. Charushin

摘要

Podands bearing phthalimide and dihydro(azolo)pyrimidine or pyrazolopyridine moieties at the ends of the oligooxyethylene spacer were synthesized. The cytotoxicity and antiviral activity against the SARS-CoV-2 coronavirus of the synthesized compounds were evaluated, and these compounds were assessed as potential inhibitors of the main protease (Mpro) of SARS-CoV-2 compared to compounds lacking this podand moiety.