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<p>The complexation of <sup>161</sup>Tb with conjugates based on the chelating agent 1,4,7,10-tetra-azacyclododecane-<i>N</i>,<i>N</i>′,<i>N</i>″,<i>N</i>‴-tetraacetic acid and new highly selective ligands targeting prostate-specific membrane antigen (PSMA) was investigated. The optimal conditions for the synthesis of the complexes were found. Five <sup>161</sup>Tb complexes with modified conjugates targeting prostate cancer were synthesized. The PSMA-selective ligands containing modified peptide sequences in the linker served as a vector platform. The stability of the resulting complexes was studied in a physiological saline solution and in solutions containing biogenic cations and fetal bovine serum.</p>

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Preparation of 161Tb complexes based on prostate-specific membrane antigen ligands and their stability

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • E. B. Furkina,
  • A. A. Uspenskaia,
  • S. A. Petrov,
  • N. Yu. Zyk,
  • P. A. Krasnikov,
  • D. V. Shpuntov,
  • A. N. Moiseeva,
  • E. K. Beloglazkina,
  • A. E. Machulkin

摘要

The complexation of 161Tb with conjugates based on the chelating agent 1,4,7,10-tetra-azacyclododecane-N,N′,N″,N‴-tetraacetic acid and new highly selective ligands targeting prostate-specific membrane antigen (PSMA) was investigated. The optimal conditions for the synthesis of the complexes were found. Five 161Tb complexes with modified conjugates targeting prostate cancer were synthesized. The PSMA-selective ligands containing modified peptide sequences in the linker served as a vector platform. The stability of the resulting complexes was studied in a physiological saline solution and in solutions containing biogenic cations and fetal bovine serum.