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<p>The effect of the solvent DMSO, as well as of hemoglobin, mucin, and glutathione, on the decomposition and NO-donor activity of the tetranitrosyl iron complex with (4-chlorophenyl)methanethiolyl [Fe<sub>2</sub>(C<sub>7</sub>H<sub>6</sub>ClS)<sub>2</sub>(NO)<sub>4</sub>] (<b>1</b>) was studied. The storage of complex <b>1</b> in DMSO leads to the coordination of the solvent, resulting in a weakening of the Fe—NO bond and, consequently, in an increase in the amount of released NO groups. Hemoglobin and glutathione have no significant effect on the process of decomposition of complex <b>1</b>, whereas in a mucin solution, complex <b>1</b> becomes a more effective and prolonged NO donor, apparently, due to the formation of mononuclear products. The interaction with mucin can play a significant role in the biotransformation of complex <b>1</b>.</p>

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Specificity of the interaction between a tetranitrosyl iron complex with (4-chlorophenyl)methanethiolyl and mucin, hemoglobin, and glutathione

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • O. V. Pokidova,
  • V. O. Novikova,
  • N. S. Emel’yanova,
  • L. M. Mazina,
  • A. V. Kulikov,
  • N. A. Sanina

摘要

The effect of the solvent DMSO, as well as of hemoglobin, mucin, and glutathione, on the decomposition and NO-donor activity of the tetranitrosyl iron complex with (4-chlorophenyl)methanethiolyl [Fe2(C7H6ClS)2(NO)4] (1) was studied. The storage of complex 1 in DMSO leads to the coordination of the solvent, resulting in a weakening of the Fe—NO bond and, consequently, in an increase in the amount of released NO groups. Hemoglobin and glutathione have no significant effect on the process of decomposition of complex 1, whereas in a mucin solution, complex 1 becomes a more effective and prolonged NO donor, apparently, due to the formation of mononuclear products. The interaction with mucin can play a significant role in the biotransformation of complex 1.