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<p>The oxofuran ring opening in 2-[(2-oxofuran-3(2<i>H</i>)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-3-carbonitriles upon the reaction with alkyl cyanoacetates and Bu<sup>t</sup>OK gave new potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (the toxicity class IV of practically nontoxic substances).</p>

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Synthesis and antinociceptive activity of potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • D. V. Lipin,
  • V. M. Shadrin,
  • S. K. Metlyakova,
  • P. S. Silaichev,
  • R. R. Makhmudov,
  • D. A. Shipilovskikh

摘要

The oxofuran ring opening in 2-[(2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles upon the reaction with alkyl cyanoacetates and ButOK gave new potassium 1-alkoxy-6-aryl-2-cyano-4-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-1,6-dioxohexa-2,4-dien-3-olates. The synthesized compounds demonstrated pronounced antinociceptive activity and low toxicity (the toxicity class IV of practically nontoxic substances).