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<p>A series of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-4,5-dihydro-1<i>H</i>-pyrrole-3-carboxylic acid derivatives was synthesized by the reaction of 4-arylamino-2-<i>tert</i>-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates with cyanoacetic acid derivatives. Some of the synthesized compounds demonstrated antihypoxic effect thus proving themselves as promising candidates for more in-depth biological studies.</p>

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Synthesis and antihypoxic activity of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-1H-4,5-dihydropyrrole-3-carboxylic acid derivatives

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • K. L. Gankova,
  • S. S. Zykova,
  • I. A. Gorbunova,
  • E. S. Denislamova,
  • D. A. Shipilovskikh,
  • R. R. Makhmudov,
  • I. N. Chernov,
  • N. M. Igidov

摘要

A series of 2-amino-1-aryl-5-(3,3-dimethyl-2-oxobutylidene)-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid derivatives was synthesized by the reaction of 4-arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates with cyanoacetic acid derivatives. Some of the synthesized compounds demonstrated antihypoxic effect thus proving themselves as promising candidates for more in-depth biological studies.