Scholarlink

<p>The oxofuran ring opening of 4-substituted <i>N</i>′-(5-aryl-2-oxofuran-3(2<i>H</i>)-ylidene)-benzhydrazides upon the reaction with different alkylamines gave new modified <i>N</i>-alkyl-2-aroylhydrazinylidene-4-oxobutanamides. The synthesized compounds demonstrated pronounced anti-inflammatory activity <i>in vivo</i> and proved themselves as promising drug candidates for the treatment of inflammation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis and study of anti-inflammatory activity of N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides

  • 期刊论文

  • 发表日期：

    2025年4月1日

查看全文
  • E. I. Denisova,
  • O. V. Zvereva,
  • D. V. Lipin,
  • S. V. Chashchina,
  • I. N. Chernov,
  • E. S. Denislamova,
  • D. A. Shipilovskikh,
  • N. M. Igidov

摘要

The oxofuran ring opening of 4-substituted N′-(5-aryl-2-oxofuran-3(2H)-ylidene)-benzhydrazides upon the reaction with different alkylamines gave new modified N-alkyl-2-aroylhydrazinylidene-4-oxobutanamides. The synthesized compounds demonstrated pronounced anti-inflammatory activity in vivo and proved themselves as promising drug candidates for the treatment of inflammation.