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<p>2-Hydroxy-3-nitro-5-ethylphenylphosphonic acid (H<sub>3</sub>L<sup>4</sup>) and its diethyl (HL<sup>5</sup>) and monoethyl (H<sub>2</sub>L<sup>6</sup>) esters were synthesized as part of our continuing research on physicochemical and biological properties of coordination compounds of bioactive metal ions with 2-hydroxyphenylphosphonic acid derivatives. The protonation constants of the compounds H<sub>3</sub>L<sup>4</sup> and H<sub>2</sub>L<sup>6</sup> and the stability constants of copper(<span>ii</span>) complexes with the acid H<sub>3</sub>L<sup>4</sup> were determined by potentiometric titration in water. The complex [Cu(H<sub>2</sub>L<sup>4</sup>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] was synthesized and its structure was suggested based on the elemental analysis data, IR spectra, electronic absorption spectra, and DFT calculations. The toxicity of the acid H<sub>3</sub>L<sup>4</sup> and the complex [Cu(H<sub>2</sub>L<sup>4</sup>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] was evaluated against the HeLa cancer cells (human cervical adenocarcinoma) and the protective effect of these compounds was studied under oxidative stress induced by hydrogen peroxide in HeLa cells.</p>

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Synthesis, structure, cytotoxicity, and antioxidant activity of 2-hydroxy-3-nitro-5-ethylphenylphosphonic acid and its complex with copper(ii)

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • V. E. Baulin,
  • G. S. Tsebrikova,
  • Yu. I. Rogacheva,
  • M. A. Lapshina,
  • I. S. Ivanova,
  • E. N. Pyatova,
  • V. P. Solov’ev,
  • A. Yu. Tsivadze

摘要

2-Hydroxy-3-nitro-5-ethylphenylphosphonic acid (H3L4) and its diethyl (HL5) and monoethyl (H2L6) esters were synthesized as part of our continuing research on physicochemical and biological properties of coordination compounds of bioactive metal ions with 2-hydroxyphenylphosphonic acid derivatives. The protonation constants of the compounds H3L4 and H2L6 and the stability constants of copper(ii) complexes with the acid H3L4 were determined by potentiometric titration in water. The complex [Cu(H2L4)2(H2O)2] was synthesized and its structure was suggested based on the elemental analysis data, IR spectra, electronic absorption spectra, and DFT calculations. The toxicity of the acid H3L4 and the complex [Cu(H2L4)2(H2O)2] was evaluated against the HeLa cancer cells (human cervical adenocarcinoma) and the protective effect of these compounds was studied under oxidative stress induced by hydrogen peroxide in HeLa cells.