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<p>Carbon nanomaterials incorporating metal ions are promising nanozymes, that is, artificial analogs of natural enzymes. Among the previously synthesized carbon dots (CDs) modified with ethylenediaminetetraacetic acid (EDTA) complexes, CDs<sub>EDTA</sub>-M (M = Fe<sup>3+</sup>, Cu<sup>2+</sup>, Ni<sup>2+</sup>, and Co<sup>2+</sup>), a pronounced peroxidase-mimicking activity was found for CDs<sub>EDTA</sub>-Fe. <i>In vitro</i> studies demonstrated low toxicity of CDs<sub>EDTA</sub> and CDs<sub>EDTA</sub>-Fe and confirmed the peroxidase-mimicking activity of CDs<sub>EDTA</sub>-Fe. The influence of the metal ion (M = Fe<sup>3+</sup>, Cu<sup>2+</sup>, Ni<sup>2+</sup>, and Co<sup>2+</sup>) on the peroxidase-mimicking catalytic activity of CDs<sub>EDTA</sub>-M was assessed using density functional theory calculations of the model H<sub>2</sub>O<sub>2</sub> reduction reaction involving [M • EDTA] complexes.</p>

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Peroxidase-mimicking activity of carbon dots modified with ethylenediaminetetraacetic acid complexes

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • G. S. Tsebrikova,
  • Yu. I. Rogacheva,
  • M. A. Lapshina,
  • Jiaxin Dong,
  • Baoqiang Li,
  • Yujin Wang,
  • V. P. Solov’ev,
  • V. E. Baulin,
  • A. Yu. Tsivadze

摘要

Carbon nanomaterials incorporating metal ions are promising nanozymes, that is, artificial analogs of natural enzymes. Among the previously synthesized carbon dots (CDs) modified with ethylenediaminetetraacetic acid (EDTA) complexes, CDsEDTA-M (M = Fe3+, Cu2+, Ni2+, and Co2+), a pronounced peroxidase-mimicking activity was found for CDsEDTA-Fe. In vitro studies demonstrated low toxicity of CDsEDTA and CDsEDTA-Fe and confirmed the peroxidase-mimicking activity of CDsEDTA-Fe. The influence of the metal ion (M = Fe3+, Cu2+, Ni2+, and Co2+) on the peroxidase-mimicking catalytic activity of CDsEDTA-M was assessed using density functional theory calculations of the model H2O2 reduction reaction involving [M • EDTA] complexes.