Scholarlink

<p>Three-component (ternary) microgels based on carboxymethylcellulose and copper(<span>ii</span>) ions with the immobilized inhibitor of inducible NO synthase (<i>N</i>-(5,6-dihydro-4<i>H</i>-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (<i>N</i>-(4-isopropylphenyl)-<i>N</i>-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic <i>Jurkat</i> cells.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Microgels based on carboxymethylcellulose as multifunctional carriers for immobilization of inhibitor and activator of inducible NO synthase

  • 期刊论文

  • 发表日期：

    2025年1月1日

查看全文
  • A. S. Zolotova,
  • M. A. Orlova,
  • V. V. Spiridonov,
  • T. P. Trofimova,
  • A. Yu. Lupatov,
  • A. A. Yaroslavov,
  • S. N. Kalmykov

摘要

Three-component (ternary) microgels based on carboxymethylcellulose and copper(ii) ions with the immobilized inhibitor of inducible NO synthase (N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide), as well as the activator of this enzyme (N-(4-isopropylphenyl)-N-(1-iminoethyl)piperidine-1-carbothioamide hydrobromide) were prepared. The hydrodynamic and electrokinetic characteristics of the microgels were studied and demonstrate an optimal size and high colloidal stability in both aqueous and physiological environments. The synthesized ternary microgels are characterized by high cytotoxicity causing apoptosis of leukemic Jurkat cells.