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<p>The investigation of the reaction of <i>N</i>-allenylpyrrole-2-carbaldehydes with phenylhydrazine demonstrated that, unlike the reactions with hydrazine hydrate, ethyl- and benzylhydrazines, it affords phenylaminopyrrolo[1,2-<i>a</i>]pyrazinium salts as the only products in nearly quantitative yields. The reaction tolerates a wide range of substituted pyrroles, as well as organic and inorganic acids. The synthesized compounds are promising building blocks for the design of pharmaceuticals and their precursors.</p>

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Assembly of phenylaminopyrrolo[1,2-a]pyrazinium salts from N-allenylpyrrole-2-carbaldehydes and phenylhydrazine in the presence of acids

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • E. A. Gyrgenova,
  • S. V. Martynovskaya,
  • I. A. Ushakov,
  • A. V. Ivanov

摘要

The investigation of the reaction of N-allenylpyrrole-2-carbaldehydes with phenylhydrazine demonstrated that, unlike the reactions with hydrazine hydrate, ethyl- and benzylhydrazines, it affords phenylaminopyrrolo[1,2-a]pyrazinium salts as the only products in nearly quantitative yields. The reaction tolerates a wide range of substituted pyrroles, as well as organic and inorganic acids. The synthesized compounds are promising building blocks for the design of pharmaceuticals and their precursors.