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<p>The trinuclear complex [Co<sub>3</sub>(3-fur)<sub>6</sub>(phen)<sub>2</sub>] (<b>1</b>; 3-fur is a 3-furancarboxylate anion, phen is 1,10-phenanthroline) was obtained by the slow diffusion of a methanol solution of cobalt(<span>ii</span>) furoate and an acetonitrile solution of 1,10-phenanthroline. The structure of complex <b>1</b> was established by X-ray diffraction analysis. According to the X-ray diffraction data, the Co<sup>II</sup> atoms are in a linear arrangement in the metal core and adopt an octahedral coordination environment formed by nitrogen and oxygen atoms, {CoO<sub>4</sub>N<sub>2</sub>} and {CoO<sub>6</sub>}, and the phenanthroline molecules are coordinated in chelate fashion to the terminal Co<sup>II</sup> atoms. The crystal packing of <b>1</b> is stabilized by π—π interactions between the phenanthroline aromatic system and the furan rings of the adjacent molecules. The biological activity of complexes <b>1</b> and [Cu(2-fur)<sub>2</sub>(phen)] was evaluated <i>in vitro</i> against phytopathogenic gram-positive and gram-negative bacteria and the model mycobacterium strain <i>Mycolicibacterium smegmatis</i>. The cytotoxic effects were assessed against SKOV3 human ovarian adenocarcinoma cells and HDF primary human dermal fibroblast cells.</p>

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Antiphytopathogenic and anticancer activity of CuII and CoII furancarboxylate complexes

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • E. A. Samoilenko,
  • K. A. Koshenskova,
  • O. V. Selitskaya,
  • L. S. Razvorotneva,
  • F. M. Dolgushin,
  • O. B. Bekker,
  • V. O. Shender,
  • I. L. Eremenko,
  • I. A. Lutsenko

摘要

The trinuclear complex [Co3(3-fur)6(phen)2] (1; 3-fur is a 3-furancarboxylate anion, phen is 1,10-phenanthroline) was obtained by the slow diffusion of a methanol solution of cobalt(ii) furoate and an acetonitrile solution of 1,10-phenanthroline. The structure of complex 1 was established by X-ray diffraction analysis. According to the X-ray diffraction data, the CoII atoms are in a linear arrangement in the metal core and adopt an octahedral coordination environment formed by nitrogen and oxygen atoms, {CoO4N2} and {CoO6}, and the phenanthroline molecules are coordinated in chelate fashion to the terminal CoII atoms. The crystal packing of 1 is stabilized by π—π interactions between the phenanthroline aromatic system and the furan rings of the adjacent molecules. The biological activity of complexes 1 and [Cu(2-fur)2(phen)] was evaluated in vitro against phytopathogenic gram-positive and gram-negative bacteria and the model mycobacterium strain Mycolicibacterium smegmatis. The cytotoxic effects were assessed against SKOV3 human ovarian adenocarcinoma cells and HDF primary human dermal fibroblast cells.