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<p>Cerium-doped calcium phosphate (Ce-CP) ceramics represent a promising class of materials for bone tissue engineering, due to their biocompatibility, and possess antioxidant, antibacterial, and osteoinductive properties. Furthermore, the application of Ce-CP ceramics in tissue-engineered constructs and materials may accelerate vascular regeneration and growth, which is critically important for the development of new methods and approaches in tissue engineering. This study is the first comprehensive review of Ce-CP ceramics, addressing possible pathways of Ce incorporation into calcium phosphate and methods of synthesis and structural characterization of Ce-CPs. Data on their biocompatibility and toxicity are summarized. The future potential of Ce-CPs in bone tissue engineering is considered.</p>

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Cerium-doped calcium phosphate materials for bone tissue engineering

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • V. K. Besprozvannykh,
  • I. E. Nifant’ev,
  • A. N. Tavtorkin,
  • P. V. Ivchenko

摘要

Cerium-doped calcium phosphate (Ce-CP) ceramics represent a promising class of materials for bone tissue engineering, due to their biocompatibility, and possess antioxidant, antibacterial, and osteoinductive properties. Furthermore, the application of Ce-CP ceramics in tissue-engineered constructs and materials may accelerate vascular regeneration and growth, which is critically important for the development of new methods and approaches in tissue engineering. This study is the first comprehensive review of Ce-CP ceramics, addressing possible pathways of Ce incorporation into calcium phosphate and methods of synthesis and structural characterization of Ce-CPs. Data on their biocompatibility and toxicity are summarized. The future potential of Ce-CPs in bone tissue engineering is considered.