New N-substituted 2,4,5-triarylimidazolines: synthesis and antitumor activity
摘要
The alkylation of 2,4,5-triarylimidazolines with allyl bromide, methallyl chloride, 2-chloromethyl-gem-dichlorocyclopropane, or 4-chloromethyl-1,3-dioxolane gave the corresponding new N-substituted derivatives. Molecular docking revealed that N-substituted 2,4,5-triarylimidazolines are capable of binding to the MDM2 protein in the way similar to nutlins. Cytotoxicity of the obtained derivatives was evaluated, and it was demonstrated that it is within the micromolar range of concentrations.