Synthesis and antimicrobial activity of alkyl[2-(5-chloro-2-hydroxyphenyl)hex-1-en-1-yl]diphenylphosphonium salts

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发表日期：

2024年12月1日

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D. A. Tatarinov,
E. A. Mikulenkova,
N. V. Terekhova,
A. V. Nemtarev,
A. P. Lyubina,
A. D. Voloshina,
A. S. Sapunova,
A. B. Dobrynin,
I. A. Litvinov,
V. F. Mironov

摘要

A series of alkyl[2-(5-chloro-2-hydroxyphenyl)hex-1-en-1-yl]diphenylphosphonium salts were synthesized based on the predicted lipophilicity (logP). The synthesized salts exhibited high antimicrobial activity against gram-positive bacterial and fungal strains and high activity against the antibiotic-resistant Staphylococcus aureus (MRSA) strains. The most active compounds showed low cytotoxicity against human erythrocytes and liver cells and exhibited high selectivity indices.