Synthesis of methylated and trifluoromethylated hydroxy thiols based on myrtenal
摘要
A new method was developed for the stereoselective synthesis of methylated and trifluoromethylated thiols based on (1R)-(–)-myrtenal. The CF3-substituted ketone and CH3-substituted thioacetate, which are required for the synthesis of the corresponding thiols, were prepared for the first time in 83% and 73% yields, respectively. The yields of CH3- and CF3-substituted thiols are 70% (de >99%) and 53% (de >99%) after two steps, respectively.