Interaction of Xymedon with l-ascorbic acid in an aqueous solution
摘要
The interaction of Xymedon (1,2-dihydro-1-(2-hydroxyethyl)-2-oxo-4,6-dimethyl-pyrimidine, 1) and l-ascorbic acid (2) in an aqueous solution was studied by the methods of potentiometric titration, spectroscopy in the UV—visible range, and mathematical simulation of equilibria (CPESSP program). The formation of a 1…2 associate was shown to take place at a wide change in the C2: C1 molar ratio, and its acidity constant was determined: pKa,111 = 4.95.