Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-4-oxo-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]-thiophen-2-yl)amino]but-2-enoic acids
摘要
The synthetic procedure was developed and the scope of the substituted 4-(het)aryl-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobut-2-enoic acids was broadened. Antinociceptive activity and acute toxicity of the synthesized compounds were studied. It was found that the synthesized substituted acids show pronounced antinociceptive activity and were classified as being practically non-toxic.