Spin crossover in new iron(ii) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine

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发表日期：

2024年11月1日

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O. G. Shakirova,
I. A. Os’kina,
E. V. Korotaev,
S. A. Petrov,
S. G. Kozlova,
L. S. Klyushova,
A. Ya. Tikhonov,
L. G. Lavrenova

摘要

New iron(ii) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine (L), viz., [FeL₂]Cl₂•2H₂O (1•2H₂O), [FeL₂](NO₃)₂•H₂O (2•H₂O), [FeL₂](ClO₄)₂•0.5H₂O (3•0.5H₂O), and [FeL₂]I₂•C₃H₆O (4•C₃H₆O) were synthesized and studied. Conclusions about the structure of the compounds are based on the diffuse reflectance, IR, and Mössbauer spectroscopy data and on the results of static magnetic susceptibility measurements and quantum chemical calculations. The temperature dependences of the effective magnetic moments of the compounds synthesized, except 1•2H₂O and 1, demonstrated features associated with spin crossover accompanied by thermochromism (changes of the color from orange to red-violet). The cytotoxic and cytostatic activity studies of the compounds in question revealed a cytostatic effect on the human hepatocellular carcinoma HepG2 cells characterized by 50% inhibitory concentration (IC₅₀) values from 44.7 ± 0.4 to 58.8 ± 0.6 µmol L⁻¹.