The first example of a ring closing metathesis in a series of anthracycline antibiotics
摘要
A ring-closing metathesis giving 3-pyrroline ring in a series of anthracycline antibiotics on the example of N,N-diallyl derivative of daunorubicin using the first and the second generation Grubbs catalysts was reported. The suggested approach can be used to synthesize new anthracycline anticancer agents.