Kinetic and thermodynamic characteristics of the azide-tetrazole rearrangement of 4,6-substituted 2-azidopyrimidines

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发表日期：

2024年9月1日

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N. V. Aleksandrova,
E. B. Nikolaenkova,
V. I. Mamatyuk,
V. P. Krivopalov

摘要

Azide-tetrazole tautomerism in a series of substituted 2-azidopyrimidines were studied by NMR spectroscopy methods. The structures of the tautomers existing in a solution were determined. By varying the temperature, the activation parameters of the studied tautomerism were determined from the integrated signal intensity in the NOESY/EXSY spectra. It was found that the phenyl substituents accelerate the tautomeric transformations.