Hydrolytic opening of the imidazole ring under action of acetylenecarboxylic acid derivatives
摘要
A three-components regioselective synthesis of 3-[2-formamidovinyl(phenyl)amino]-acrylic acid based on an opening of the imidazole ring under the influence of acetylene carboxylic acids esters or cyanophenylacetylene in aqueous acetonitrile in up to 86% yields has been developed.