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Synthesis of (bi)pyridine derivatives of ornidazole

  • E. A. Kudryashova,
  • M. I. Valieva,
  • N. V. Slovesnova,
  • A. V. Bolotova,
  • Yu. M. Sayfutdinova,
  • S. E. Vatolina,
  • I. L. Nikonov,
  • K. V. Grzhegorzhevskii,
  • D. S. Kopchuk,
  • G. V. Zyryanov,
  • V. L. Rusinov

摘要

New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.