Synthesis and spatial structure of 3,7-dihydroxy-7-(trifluoromethyl)hexahydropyrrolo[1,2-a]pyrimidines

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发表日期：

2024年8月1日

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M. V. Goryaeva,
M. A. Ezhikova,
Ya. V. Burgart,
M. S. Kustova,
M. I. Kodess,
P. A. Slepukhin,
V. I. Saloutin

摘要

A characteristic feature of the three-component cyclization of ethyl trifluoropyruvate and methyl ketones with 1,3-diamino-2-propanol is the formation of 8a-alkyl(phenyl)-3,7-dihydroxy-7-(trifluoromethyl)hexahydropyrrolo[1,2-a]pyrimidin-6(2H)-ones as one, two, or three diastereomers, depending on the methyl ketone component. The structures of the new heterocycles were established using the data of X-ray diffraction and ¹H and ¹³C NMR spectra, including 2D ¹H—¹³C HSQC, HMBC, ¹H—¹H COSY, and NOESY experiments.