Modification of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide using S_N^H and click reactions

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发表日期：

2024年8月1日

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V. E. Petrova,
I. S. Kovalev,
G. V. Zyryanov,
V. L. Rusinov

摘要

The applicability of S_N^H and click reactions in the series of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide and its derivatives for the synthesis of distant analogs of folic acid and fluorophores was studied. The target products were synthesized in the yields up to 81%, and their structures were proved by ¹H NMR spectroscopy and mass spectrometry.

Modification of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide using SNH and click reactions

摘要

Modification of 2-amino-5-bromomethyl-3-(ethoxycarbonyl)pyrazine 1-oxide using S_N^H and click reactions