Titanocene-catalyzed selective synthesis of 2,4-dialkyl-6-(2-methoxyethyl)pyridines by the reaction of terminal acetylenes with 3-methoxypropionitrile

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发表日期：

2024年8月1日

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M. G. Shaibakova,
E. I. Titova,
L. K. Dil’mukhametova,
I. R. Ramazanov

摘要

A selective one-pot method was developed for the synthesis of 2,4-dialkyl-6-(2-methoxyethyl)pyridines in yields of 70–82% by the reaction of terminal acetylenes with 3-methoxypropionitrile in the presence of EtAlCl₂, Mg, and Cp₂TiCl₂ (10 mol.%).