One-pot synthesis of spirocyclopropane-fused tetrahydrofurans by the Cp₂ZrCl₂-catalyzed reaction of styrene with butyrolactones in the presence of AlCl₃ and Mg

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发表日期：

2024年7月1日

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L. K. Dilmukhametova,
M. G. Shaibakova,
I. R. Ramazanov

摘要

The reaction of styrene with butyrolactones in the presence of 2 equiv. each of AlCl₃ and Mg and catalyzed by 10 mol.% of Cp₂ZrCl₂ in tetrahydrofuran led to the corresponding 1-phenyl-4-oxaspiro[2.4]heptanes in 47–57% yield. Presumably, the intermediates are zirconacyclopropane derivatives, similar to the Kulinkovich reagents.

One-pot synthesis of spirocyclopropane-fused tetrahydrofurans by the Cp2ZrCl2-catalyzed reaction of styrene with butyrolactones in the presence of AlCl3 and Mg

摘要

One-pot synthesis of spirocyclopropane-fused tetrahydrofurans by the Cp₂ZrCl₂-catalyzed reaction of styrene with butyrolactones in the presence of AlCl₃ and Mg