Chemo-, regio-, and stereoselective catalyst-free addition of diphenylphosphine oxide to acetylenic amino ketones. Synthesis of Z-diphenylphosphoryl(organylamino)alkenones

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发表日期：

2024年6月1日

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S. I. Verkhoturova,
P. A. Volkov,
I. A. Bidusenko,
S. N. Arbuzova,
S. V. Zinchenko,
B. A. Trofimov

摘要

Catalyst-free addition of diphenylphosphine oxide to 1,4-diorganyl-4-(organylamino)-alk-2-yn-1-ones proceeded chemo-, regio-, and stereoselectively to afford new Z-3-diphenylphosphoryl-1,4-diorganyl-4-(organylamino)alk-2-en-1-ones in up to 75% yield. The synthesized compounds are promising candidates for organic synthesis and pharmaceutical research.