Rearrangement of 3-(bromomethyl)quinoxalin-2(1H)-ones when exposed to 2-aminopyridines as a new method for the synthesis of 2-(imidazo[1,2-a]pyridin-2-yl)benzimidazoles

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发表日期：

2024年6月1日

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N. A. Zhukova,
D. S. Perevalova,
V. V. Syakaev,
T. N. Beschastnova,
A. T. Gubaidullin,
O. G. Sinyashin,
V. A. Mamedov

摘要

A new efficient method was developed for the synthesis of 2-(imidazo[1,2-a]pyridin-2-yl)benzimidazoles based on the Mamedov rearrangement. The key step of the synthesis involves the acid-catalyzed rearrangement of spiroquinoxalinone derivatives as intramolecular cyclization products of 2-amino-1-[(quinoxalin-2(1H)-on-3-yl]methyl)pyridinium salts, which are generated by the modified Chichibabin reaction.