Simple synthesis of erythro-2,3,6-trimethylhepta-4,6-dien-1-ol acetate, a lasiol precursor
摘要
The Wittig reaction of (methallylidene)triphenylphosphorane with erythro-4-acetoxy-2,3-dimethylbutanal afforded erythro-2,3,6-trimethylhepta-4,6-dien-1-yl acetate as a mixture of E and Z isomers in a 85: 15 ratio. 1,4-cis-Hydrogenation of the conjugated diene system in the obtained isomeric mixture provided individual acetate of lasiol (erythro-2,3,6-trimethylhept-5-en-1-ol).