N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles
摘要
Alkylation of isomeric methyl nitropyrazolecarboxylates with bromoacetone followed by acid hydrolysis gave new N-acetonylnitropyrazolecarboxylic acids. A selective synthesis of 3-R-5-(N-acetonylnitropyrazolyl)-1,2,4-oxadiazoles based on the reaction of nitropyrazolecarboxylic acid chlorides with isomeric amidoximes of nitropyrazoles and aminofurazan was developed. The possibility to introduce the second N-acetonyl group into di(nitropyrazolyl)-1,2,4-oxadiazoles was studied.