Ammonium acylhydrazones based on 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde: synthesis, possibilities of functionalization, and evaluation of biological activity

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发表日期：

2024年3月1日

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A. V. Bogdanov,
S. V. Bukharov,
A. N. Yusupov,
I. A. Litvinov,
A. D. Voloshina,
R. G. Tagasheva,
E. V. Kolpakova

摘要

The reaction of 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde with analogs of Girard’s reagents was used to synthesize new water-soluble ammonium acylhydrazones as individual E_C=N,syn_N-C(O) isomers. The introduction of an additional sterically hindered phenolic moiety into ammonium N-acylhydrazone leads to the emergence of antimicrobial activity against gram-negative pathogens of bacterial (Pseudomonas aeruginosa, Escherichia coli) and fungal origin (Candida albicans).