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Unusual reaction of 16α,17α-epoxypregn-5-en-20-one derivative with hydroxylamine

  • A. V. Komkov,
  • L. G. Menchikov,
  • A. S. Dmitrenok,
  • N. G. Kolotyrkina,
  • I. V. Zavarzin

摘要

The reaction of hydroxylamine and steroid obtained by the condensation of 16α,17α-epoxypregn-5-en-20-one with DMF dimethyl acetal proceeded through the involvement of the epoxide fragment and led to the formation of 3β-hydroxy-4′-hydroxylaminoandrost-5-eno[16,17-b]pyridine l′-N-oxide.