Synthesis and antimicrobial activity of new thiomonoterpene carboxylic acids
摘要
A series of new compounds containing monoterpenoid fragments, sulfide and carboxy groups was synthesized. The reaction of monoterpene thiols with bromoacetic acid and ethyl 2-bromo-2,2-difluoroacetate afforded new thiomonoterpene carboxylic acids in 80–96% and 56–80% yields, respectively. The synthesized compounds were studied for antimicrobial activity. Some structure–property interrelations were revealed, which depended on the monoterpene fragment structure and the presence of fluorine atoms in the carboxymethyl group.