Synthesis and antibacterial activity of new bis-quaternary ammonium compounds based on polyhydric alcohol
摘要
The synthesis of bis-quaternary ammonium compounds based on a polyhydric alcohol, 2,3-bis(hydroxymethyl)butane-1,4-diol, and pyridine was accomplished. The bacteriostatic and bactericidal activity of the products against ESKAPE pathogens and Candida albicans yeast-like fungus both in planktonic and biofilm forms was studied. The activity of the bis-pyridinium salts was compared with the activities of known antiseptic agents, octenidine dihydrochloride and cetylpyridinium chloride. It was found that the compound containing ten carbon atoms in the alkyl group is effective against various strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and C. albicans.