Physicochemical characteristics and antiproliferative activity of a water-soluble nanoformulation of the Pt^IV complex with a lonidamine-based ligand

Water-soluble nanoformulation of a hydrophobic anticancer Pt^IV complex with a lonidamine-based ligand has been developed. Biodegradable nanocarriers (13 nm) obtained from poly(l-lactide-block-polyethylene glycol) star-shaped block copolymers were used to create the formulation. The loading of the active agent into nanoparticles was up to 3.7 wt.%, and the loading efficiency was up to 68%. It was shown that solubilization of the anticancer complex into polymeric nanoparticles did not lead to a significant decrease in its cytotoxicity. As the number of arms in the star-shaped block copolymers increased, the selectivity of the nanoformulations towards cancer cells tended to increase.