Scholarlink

<p>The preparation of biologically active compounds, such as enaminones, has been continuously scrutinized in the search for the best catalyst to make the process greener, more efficient, and more sustainable. The present article discloses the fabrication of a bimetallic Pd-Cu-anchored cellulose-supported metal–organic framework i.e. RH-CNC@NH<sub>2</sub>-BDC-Fe@Pd-Cu, where RH-CNC was derived from agrowaste rice husk. The formation of the catalyst was confirmed by various physicochemical characterizations using FTIR, Raman, FESEM, EDX, XRD, XPS, BET, and TGA, which indicate successful immobilization, structural integrity, and magnetic recoverability. The fabricated catalyst was used to synthesize enaminone derivatives from dimedone via a sequential one-pot Heck coupling reaction. The enaminone product <b>5a</b> was further explored for the synthesis of a bioactive azepinone framework. To assess the catalyst efficacy, the reaction was studied with a series of substrates, yielding excellent yields and remarkable catalytic cycles.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Novel synthesis and functionalization of enaminone intermediate using bimetallic Pd-Cu anchored cellulose supported-MOF via heck coupling reaction

  • 期刊论文

  • 发表日期：

    2026年7月25日

查看全文
  • Khushboo Bhardwaj,
  • Shivangi Jaiswal,
  • Nisha Saini,
  • Annu Bhardwaj,
  • Archana Shau,
  • Deepika Arora,
  • Swapnil Sharma,
  • Jaya Dwivedi

摘要

The preparation of biologically active compounds, such as enaminones, has been continuously scrutinized in the search for the best catalyst to make the process greener, more efficient, and more sustainable. The present article discloses the fabrication of a bimetallic Pd-Cu-anchored cellulose-supported metal–organic framework i.e. RH-CNC@NH2-BDC-Fe@Pd-Cu, where RH-CNC was derived from agrowaste rice husk. The formation of the catalyst was confirmed by various physicochemical characterizations using FTIR, Raman, FESEM, EDX, XRD, XPS, BET, and TGA, which indicate successful immobilization, structural integrity, and magnetic recoverability. The fabricated catalyst was used to synthesize enaminone derivatives from dimedone via a sequential one-pot Heck coupling reaction. The enaminone product 5a was further explored for the synthesis of a bioactive azepinone framework. To assess the catalyst efficacy, the reaction was studied with a series of substrates, yielding excellent yields and remarkable catalytic cycles.

Graphical abstract