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<p>This study presents the synthesis of a new efficient purine-sulfonic acid ionic liquid immobilized onto magnetic nanosilica (SiO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub>@Purine-SO<sub>3</sub>H). The synthesis of this nanocatalyst started by immobilizing purine onto magnetic nanosilica, followed by treatment with 1,3-propane sultone and subsequent acidification by H<sub>2</sub>SO<sub>4</sub>. The structure of the nanocatalyst was comprehensively characterized using FT-IR, TGA, SEM, VSM, XRD, BET, EDS, ICP and elemental analysis techniques. The catalytic activity of the introduced nanocatalyst was investigated in the synthesis of dihydropyrimidine derivatives, achieving high to excellent yields (75–94%) within 40&#xa0;min at room temperature in ethanol, using only 20&#xa0;mg of nanocatalyst. The results showed that the immobilized ionic liquid significantly enhanced the catalytic activity by increasing surface acidity and dispersion. This method offers a green, efficient, and reusable catalytic system for heterocyclic synthesis, featuring mild reaction conditions, a simple operational procedure, and facile nanocatalyst recovery.<MediaObject ID="MO100"> <ImageObject Color="Color" FileRef="MediaObjects/11164_2025_5834_Figa_HTML.png" Format="PNG" Height="954" Rendition="HTML" Resolution="300" Type="LinedrawHalftone" Width="1383" /> </MediaObject></p>

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SiO₂@Fe3O4@Purine-SO3H: a robust solid acid nanocatalyst for accelerated Biginelli condensation

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Somayeh Darvishy,
  • Sakineh Asghari,
  • Mahmood Tajbakhsh,
  • Robabeh Baharfar

摘要

This study presents the synthesis of a new efficient purine-sulfonic acid ionic liquid immobilized onto magnetic nanosilica (SiO2@Fe3O4@Purine-SO3H). The synthesis of this nanocatalyst started by immobilizing purine onto magnetic nanosilica, followed by treatment with 1,3-propane sultone and subsequent acidification by H2SO4. The structure of the nanocatalyst was comprehensively characterized using FT-IR, TGA, SEM, VSM, XRD, BET, EDS, ICP and elemental analysis techniques. The catalytic activity of the introduced nanocatalyst was investigated in the synthesis of dihydropyrimidine derivatives, achieving high to excellent yields (75–94%) within 40 min at room temperature in ethanol, using only 20 mg of nanocatalyst. The results showed that the immobilized ionic liquid significantly enhanced the catalytic activity by increasing surface acidity and dispersion. This method offers a green, efficient, and reusable catalytic system for heterocyclic synthesis, featuring mild reaction conditions, a simple operational procedure, and facile nanocatalyst recovery.