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<p>In this study, a straightforward and eco-friendly approach was developed for the synthesis of biocompatible compounds that include manganese and tannic acid covalently linked with β-cyclodextrin (Mn/TA-βCD and MnTA/βCD). Additionally, a MnO<sub>2</sub>/TA-βCD composite was prepared for comparison. FT-IR, UV–vis, TGA, and Fluorescence techniques were used to characterize the prepared samples. TGA analysis demonstrated that MnTA/βCD had better thermal stability than Mn/TA-βCD. An interaction between β-cyclodextrin and tannic&#xa0;acid was confirmed by the fluorescence spectrum. The introduction of tannic acid into the β-cyclodextrin further improved the in vitro antioxidant potential. According to the pyrogallol autoxidation, MnTA/βCD exhibited the highest SOD-like activity (93%), and MnO<sub>2</sub>/TA-βCD demonstrated superior efficacy in scavenging hydrogen peroxide (94%). In addition, MTT assay studies confirmed the non-cytotoxic nature of the compounds.</p>

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Biocompatible manganese-tannic acid-βcyclodextrin compounds as catalytic antioxidants

  • 期刊论文

  • 发表日期：

    2025年11月7日

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  • Mahtab Pirouzmand,
  • Nardin Mosanaei Najibi,
  • Saeedeh Khadivi-Derakhshan,
  • Adel Mahmoudi Gharehbaba,
  • Jafar Soleymani

摘要

In this study, a straightforward and eco-friendly approach was developed for the synthesis of biocompatible compounds that include manganese and tannic acid covalently linked with β-cyclodextrin (Mn/TA-βCD and MnTA/βCD). Additionally, a MnO2/TA-βCD composite was prepared for comparison. FT-IR, UV–vis, TGA, and Fluorescence techniques were used to characterize the prepared samples. TGA analysis demonstrated that MnTA/βCD had better thermal stability than Mn/TA-βCD. An interaction between β-cyclodextrin and tannic acid was confirmed by the fluorescence spectrum. The introduction of tannic acid into the β-cyclodextrin further improved the in vitro antioxidant potential. According to the pyrogallol autoxidation, MnTA/βCD exhibited the highest SOD-like activity (93%), and MnO2/TA-βCD demonstrated superior efficacy in scavenging hydrogen peroxide (94%). In addition, MTT assay studies confirmed the non-cytotoxic nature of the compounds.