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<p>We have developed an eco-friendly method for synthesizing hexahydroquinoline-3-carboxamide derivatives using guanidine hydrochloride as a catalyst in water. This one-pot, multicomponent reaction combines aromatic or heteroaromatic aldehydes, dimedone, acetoacetanilide, and ammonium acetate to produce high yields of the desired compounds. The catalyst also showed remarkable reusability, maintaining its effectiveness over five successive cycles without notable degradation. The approach boasts several advantages, including a sustainable reaction profile, streamlined processing, rapid reaction times, and efficient atom economy, making it an appealing and environmentally responsible approach.</p> Graphical abstract <p></p>

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Guanidine hydrochloride-catalyzed synthesis of hexahydroquinoline-3-carboxamide derivatives in aqueous medium: an efficient and expeditious approach

  • 期刊论文

  • 发表日期：

    2025年10月3日

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  • Angad B. Barkule,
  • Yatin U. Gadkari,
  • Savita B. Lomte,
  • Shrikant M. Ghodse,
  • Vikas N. Telvekar

摘要

We have developed an eco-friendly method for synthesizing hexahydroquinoline-3-carboxamide derivatives using guanidine hydrochloride as a catalyst in water. This one-pot, multicomponent reaction combines aromatic or heteroaromatic aldehydes, dimedone, acetoacetanilide, and ammonium acetate to produce high yields of the desired compounds. The catalyst also showed remarkable reusability, maintaining its effectiveness over five successive cycles without notable degradation. The approach boasts several advantages, including a sustainable reaction profile, streamlined processing, rapid reaction times, and efficient atom economy, making it an appealing and environmentally responsible approach.

Graphical abstract