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<p>A highly efficient and environmentally benign method has been developed for the synthesis of 3-methyl-4-arylmethylene isoxazole-5(4<i>H</i>)-ones using a recyclable catalyst [Msim]Cl. Under the optimized conditions, the target compounds were obtained in excellent yields. Notably, 4-(2-naphthobenzylidene)-3-methylisoxazol-5(4<i>H</i>)-one (I-6) exhibited remarkable in vitro anti-bacterial and anti-cancer activities highlighting its potential as a promising lead compound for future pharmaceutical development.</p> Graphical abstract <p></p>

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Development of bioactive isoxazole derivatives via ionic liquid catalysis: synthesis, characterization, and pharmacological evaluation

  • 期刊论文

  • 发表日期：

    2025年8月28日

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  • Vaishali V. Patil,
  • Swapnali S. Patil,
  • Swati D. Jadhav

摘要

A highly efficient and environmentally benign method has been developed for the synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H)-ones using a recyclable catalyst [Msim]Cl. Under the optimized conditions, the target compounds were obtained in excellent yields. Notably, 4-(2-naphthobenzylidene)-3-methylisoxazol-5(4H)-one (I-6) exhibited remarkable in vitro anti-bacterial and anti-cancer activities highlighting its potential as a promising lead compound for future pharmaceutical development.

Graphical abstract