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<p>The development of methodologies that are both sustainable and efficient remains one of the most important goals in contemporary chemical synthesis. This study focuses on the synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives, which are biologically and pharmaceutically significant compounds, using a green and highly efficient approach. The reaction takes place in the absence of solvents, employing a magnetically separable Fe₃O₄@SiO₂@CeO₂ nanocatalyst, which is more ecological. This method has a number of advantages, including high yields of the desired products, fast reaction time, and easy separation and reuse of the catalysts. In addition to these benefits, the method tolerates an extensive scope of substrates, allowing condensation of various benzaldehydes, malononitrile and resorcinol derivatives in one reaction vessel. The outcome demonstrates the efficiency of magnetically separable nanocatalyst in performing organic reactions under environmentally friendly conditions, thus fostering the development of green chemistry.</p> Graphical Abstract <p></p>

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Greener and efficient route for the synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile by employing magnetically recoverable Fe₃O₄@SiO₂@CeO2 nanocatalyst under solvent-free conditions

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Gayatree Shinde,
  • Jyotsna Thakur

摘要

The development of methodologies that are both sustainable and efficient remains one of the most important goals in contemporary chemical synthesis. This study focuses on the synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives, which are biologically and pharmaceutically significant compounds, using a green and highly efficient approach. The reaction takes place in the absence of solvents, employing a magnetically separable Fe₃O₄@SiO₂@CeO₂ nanocatalyst, which is more ecological. This method has a number of advantages, including high yields of the desired products, fast reaction time, and easy separation and reuse of the catalysts. In addition to these benefits, the method tolerates an extensive scope of substrates, allowing condensation of various benzaldehydes, malononitrile and resorcinol derivatives in one reaction vessel. The outcome demonstrates the efficiency of magnetically separable nanocatalyst in performing organic reactions under environmentally friendly conditions, thus fostering the development of green chemistry.

Graphical Abstract