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<p>This study describes a benign, rapid, and highly efficient practical approach for synthesizing bis(6-amino-1,3-dimethyluracil-5-yl) methanes using 1,4-bis(pyridin-1-ium)benzene trifluoroacetate coordinated to chloropropyl functionalized SiO<sub>2</sub>-nano-NiFe<sub>2</sub>O<sub>4</sub> (BPTCSBF) as a bi-functional and reusable mesoporous catalyst in a recyclable green media. The catalytic scope of bi-functional BPTCSBF with acidic (~ NH<sup>+</sup>) and basic (CF<sub>3</sub>COOˉ) sites was very broad and useful, as it rapidly produced products (1a–15a) from the reaction of various aryl-aldehydes with 6-amino-1,3-dimethyluracil in excellent yields (90–98%, 7–17&#xa0;min) under optimal conditions (0.01&#xa0;g catalyst, 60&#xa0;°C, 1&#xa0;mL EtOH:H<sub>2</sub>O). This generality and high functionality were backed by the presentation of a rational mechanism. Easy magnetic separation of the catalyst with an external magnet, suitable one-pot procedure, high reproducibility of the catalyst with brilliant performance up to eight cycles, mild temperature, easy work-up, and synthesis/characterization of new derivatives to the literature are other highlights of the current work.</p> Graphical Abstract <p></p>

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Application of a mesoporous structure as an efficient catalyst for the rapid and green synthesis of uracil derivatives in a recyclable environment

  • 期刊论文

  • 发表日期：

    2025年7月7日

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  • Eman A. Alabdullkarem,
  • Saad Alrashdi,
  • Mohammed Asiri,
  • Fadhil Sead,
  • Subbulakshmi Ganesan,
  • Subhashree Ray,
  • Aashna Sinha,
  • Krishan Kumar Sah,
  • I. B. Sapaev,
  • Yassin T. H. Mehdar

摘要

This study describes a benign, rapid, and highly efficient practical approach for synthesizing bis(6-amino-1,3-dimethyluracil-5-yl) methanes using 1,4-bis(pyridin-1-ium)benzene trifluoroacetate coordinated to chloropropyl functionalized SiO2-nano-NiFe2O4 (BPTCSBF) as a bi-functional and reusable mesoporous catalyst in a recyclable green media. The catalytic scope of bi-functional BPTCSBF with acidic (~ NH+) and basic (CF3COOˉ) sites was very broad and useful, as it rapidly produced products (1a–15a) from the reaction of various aryl-aldehydes with 6-amino-1,3-dimethyluracil in excellent yields (90–98%, 7–17 min) under optimal conditions (0.01 g catalyst, 60 °C, 1 mL EtOH:H2O). This generality and high functionality were backed by the presentation of a rational mechanism. Easy magnetic separation of the catalyst with an external magnet, suitable one-pot procedure, high reproducibility of the catalyst with brilliant performance up to eight cycles, mild temperature, easy work-up, and synthesis/characterization of new derivatives to the literature are other highlights of the current work.

Graphical Abstract